کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2545790 | 1124003 | 2010 | 4 صفحه PDF | دانلود رایگان |
Aim of the studyThe present study aimed to investigate the effects of Scutellariae radix (SR) and Aloe vera gel (AV), alone or in combination, on levels of immunoglobulin E (IgE) and inflammatory cytokines in spontaneous atopic dermatitis(AD)-like skin lesions.Materials and methodsAfter spontaneous AD-like skin lesion was developed by adaptation to conventional conditions, mice were randomly assigned to control, SR (50 mg/kg, p.o.), AV (0.8 mg/kg, p.o.) and SRAV (50 mg of SR and 0.8 mg of AV/kg, p.o.) groups, and were treated for 6 weeks.ResultsSR and SRAV suppressed IL-5 levels compared with control, but had no effects on IgE levels (P < 0.05). AV increased IgE levels, but decreased both IL-5 and IL-10 compared with control (P < 0.05).ConclusionThese results suggest that SR and AV modulate immunological responses in AD, mainly through influencing IL-5 or IL-10 levels.
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Journal: Journal of Ethnopharmacology - Volume 132, Issue 2, 11 November 2010, Pages 529–532