کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2545801 1124005 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Renaissance remedies: Antiplasmodial protostane triterpenoids from Alisma plantago-aquatica L. (Alismataceae)
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Renaissance remedies: Antiplasmodial protostane triterpenoids from Alisma plantago-aquatica L. (Alismataceae)
چکیده انگلیسی

Aim of the studyIn a preliminary screen of extracts from plants used as antimalarial remedies used in Europe in the 16th and 17th, the ethyl acetate extract of Alisma plantago-aquatica L. (Alismataceae) was active against Plasmodium falciparum K1 strain with 77% growth inhibition at 4.9 μg/ml. The aim of this study was to isolate and identify the substances responsible for this antiplasmodial activity.Materials and methodsWith HPLC-based activity profiling in combination with HPLC hyphenated methods (HPLC–PDA, –MSn, HR–MS, and off-line microprobe NMR) the activity was assigned to time windows, and the substances contained therein were characterised chemically. The active compounds were isolated with semi-preparative HPLC and structures were elucidated with high resolution mass spectrometry, and 1D and 2D NMR spectroscopy.ResultsFour compounds were isolated and identified as protostane triterpenoids alisol A, alisol B 11-monoacetate, alisol B 23-monoacetate, and alisol G. Their IC50s against Plasmodium falciparum ranged from 5.4 to 13.8 μM.ConclusionsThis is the first report of antiplasmodial activity from protostanes triterpenoids, and the first result of our ongoing project of screening for antiprotozoal natural products from remedies used in European renaissance medicine.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 135, Issue 1, 26 April 2011, Pages 43–47
نویسندگان
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