کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2545880 1124010 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thymoquinone-induced relaxation of isolated rat pulmonary artery
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Thymoquinone-induced relaxation of isolated rat pulmonary artery
چکیده انگلیسی

Aim of the studyThe effect of thymoquinone (TQ), the main constituent of the volatile oil of black seed (Nigella sativa L. family Ranunculaceae), on the isolated rat pulmonary arterial rings was investigated.Materials and methodsIsolated rat pulmonary arterial rings were precontracted with phenylephrine and concentration–response curves to TQ were constructed. The effects of different receptors antagonists or enzyme inhibitors were examined.ResultsTQ caused a concentration-dependent decrease in the tension of the pulmonary arterial rings precontracted by phenylephrine. The effects of TQ were not influenced by pretreatment of the rings with propranolol (a non-selective β-blocker), atropine (a non-selective blocker for muscarinic receptors), theophylline (an adenosine receptor antagonist), indomethacin (a cyclooxygenase inhibitor), L-NAME (a NO synthase inhibitor), methylene blue (an inhibitor of soluble guanylyl cyclase) and nifedipine (a Ca2+ channel blocker). The effects of TQ were significantly potentiated by bosentan (an ETA/ETB receptor antagonist). The effects of TQ were slightly abolished by pretreatment of the rings with glibenclamide (a non-selective blocker of ATP-sensitive K+ channels). TQ totally abolished the pressor effects of serotonin and phenylephrine on the isolated rat pulmonary arterial rings.ConclusionThe results of the present study suggest that TQ-induced relaxation of the precontracted pulmonary artery is probably mediated, at least in part, by activation of ATP-sensitive potassium channels and possibly by non-competitive blocking of serotonin, α1 and endothelin receptors.

The effect of thymoquinone (TQ) on the isolated rat pulmonary arterial rings was investigated. TQ caused a concentration-dependent decrease in the tension of the pulmonary arterial rings precontracted by phenylephrine. The results of the present study suggest that TQ-induced relaxation of the precontracted pulmonary artery is probably mediated, at least in part, by activation of ATP-sensitive potassium channels and possibly by non-competitive blocking of serotonin, α1 and endothelin receptors.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 127, Issue 2, 3 February 2010, Pages 210–214
نویسندگان
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