کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2545895 1124010 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: Possible involvement of adenosine
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: Possible involvement of adenosine
چکیده انگلیسی

Ethnopharmacological relevanceValeriana officinalis L. (valerian) root extract has been used as an antiepileptic herbal medicine in Iran.Aim of this studyIn the present study the effect of valerian extracts on an experimental model of temporal lobe epilepsy (TLE) was evaluated. Moreover, the involvement of adenosine system in the actions of aqueous extract of valerian was evaluated.Materials and methodsBipolar stimulating and monopolar recording electrodes were implanted stereotaxically in the right basolateral amygdala of male Sprague–Dawley rats. After kindling, the effect of aqueous (200, 500 and 800 mg/kg; intraperitoneal) and petroleum ether (PE; 50 and 100 mg/kg; intraperitoneal) extracts of valerian and CPT (selective A1 receptor antagonist; 10 and 20 μM; intracerebroventricular) on afterdischarge duration (ADD), duration of stage 5 seizure (S5D) and latency to the onset of bilateral forelimb clonuses (S4L) were measured. The effect of CPT (10 μM) on the response of aqueous extract of valerian (500 mg/kg) was also determined.ResultsThe results showed that aqueous extract of valerian had anticonvulsant effect. However, PE extract and CPT (20 μM) had proconvulsant effect. Administration of CPT (10 μM) before the administration of aqueous extract decreased the anticonvulsant effect of valerian.ConclusionsThe results showed significant anticonvulsant effect for aqueous but not PE extract of valerian. Moreover, CPT as a selective adenosine A1 receptor antagonist decreased the anticonvulsant effect of valerian aqueous extract. Therefore, we concluded that part of anticonvulsant effect of valerian probably is mediated through activation of adenosine system.

Aqueous but not petroleum ether extract of Valeriana officinalis had anticonvulsant effects on an animal model of temporal lobe epilepsy. These effects were decreased in the presence of CPT as an A1 receptor selective antagonist.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 127, Issue 2, 3 February 2010, Pages 313–318
نویسندگان
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