کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2546195 | 1124018 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The effects of the Chinese herbal medicine EMF01 on salicylate-induced tinnitus in rats The effects of the Chinese herbal medicine EMF01 on salicylate-induced tinnitus in rats](/preview/png/2546195.png)
Aim of the studyTraditional Chinese medicine (TCM) has been reported to successfully alleviate tinnitus, although well-controlled studies have not been conducted. In this study, we attempted to test a TCM, Er Ming Fang (EMF01) containing Rehmannia glutinosa, Cornus officinalis, Salvia mittiorrhiza, Pueraria, Schisandra chinensis, Poria cocos and Platycodon grandiflorum, on salicylate-induced tinnitus in rats, using a conditioned lick suppression paradigm.Materials and methodsA pilot study examined the effect of 8.75 g/kg and 17.5 g/kg EMF01 (delivered by oral gavage for 20 days) and showed a slight decrease in the suppression ratio (SR) in the 8.75 g/kg group. In order to confirm the possible effect of EMF01 on tinnitus at 8.75 g/kg, a further study was carried out with a larger sample size.ResultsWhile there were statistically significant differences between the treatment groups, post hoc tests revealed that EMF01 did not have any significant effect on salicylate-induced tinnitus.ConclusionsWhile this study does not support the efficacy of EMF01 in the treatment of salicylate-induced tinnitus, further studies should be conducted to determine if it alleviates tinnitus associated with acoustic trauma.
Journal: Journal of Ethnopharmacology - Volume 128, Issue 2, 24 March 2010, Pages 545–548