کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2546347 1124023 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of anticancer activity of Cleome gynandra on Ehrlich's Ascites Carcinoma treated mice
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Evaluation of anticancer activity of Cleome gynandra on Ehrlich's Ascites Carcinoma treated mice
چکیده انگلیسی

Ethnopharmacological relevanceThe plant Cleome gynandra L. (Capparidaceae), is commonly known as ‘Hurhur’and ‘Karaila’ in India and ‘Cat's whiskers’ in English. Traditionally the whole plant is used in the treatment of tumor, anti-inflammatory and lysosomal stability actions.Aim of studyThe objective of present study is to explore the anticancer activity of the methanol extract of the Cleome gynandra in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line.Materials and methodsAnticancer activity of methanol extract of Cleome gynandra (MECG) was evaluated in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line at the doses of 200 and 400 mg/kg body weight intraperitoneally. MECG was administered for nine consecutive days. Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and antitumor effect of MECG assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host.ResultsMECG showed significant decrease in (p < 0.01) tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Hematological profile such as RBC, hemoglobin, WBC and lymphocyte count reverted to normal level in MECG treated mice.ConclusionFrom the result it was showed that the extract has potent dose dependent anticancer activity and that is comparable to that of 5-fluorouracil.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 129, Issue 1, 4 May 2010, Pages 131–134
نویسندگان
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