کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2546571 1124030 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antidepressant-like effect of peony glycosides in mice
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Antidepressant-like effect of peony glycosides in mice
چکیده انگلیسی

Aim of the studyThe root part of Paeonia lactiflora Pall. (Ranunculaceae), known as peony, is often used in Chinese herbal formulae for the treatment of depression-like disorders. Previous studies in our laboratory have shown that an ethanol extract of peony produced antidepressive effects in mouse models of depression. It is well known that peony contains glycosides such as paeoniflorin and albiflorin, yet it remains unclear whether the total glycosides of peony (TGP) are effective. The present study aims to evaluate the antidepressant-like effects of TGP.Materials and methodsThe antidepressant-like effects of TGP was determined by using animal models of depression including forced swim and tail suspension tests. The acting mechanism was explored by determining the effect of TGP on the activities of monoamine oxidases.ResultsIntragastric administration of TGP at 80 and 160 mg/kg for seven days caused a significant reduction of immobility time in both forced swim and tail suspension tests, yet TGP did not stimulate locomotor activity in the open-field test. In addition, TGP treatment antagonized reserpine-induced ptosis and inhibited the activities of monoamine oxidases in mouse cerebrum.ConclusionThese results suggest that the antidepressive effects of TGP are mediated, at least in part, by the inhibition of monoamine oxidases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 119, Issue 2, 26 September 2008, Pages 272–275
نویسندگان
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