کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2546656 1124032 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Safety of the traditional Korean herbal medicine CGX: A 6-month repeated-dose study in rats
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Safety of the traditional Korean herbal medicine CGX: A 6-month repeated-dose study in rats
چکیده انگلیسی

Ethnopharmacological relevanceCGX is a traditional Korean herbal medicine used to treat chronic liver diseases.Aim of studyThe purpose of this study was to evaluate the pharmaceutical safety of hepatoprotective herbal medicine, CGX via systemic 6-month repeated dose toxicity study in SD rats.Materials and methodsMale and female SD rats were administered CGX for 6 months (0, 100, 200, or 400 mg kg−1, respectively). The rats were visually inspected for changes in behavior, body weight, food and water consumption, and appearance during the experiment period. At the end of the experiment, urine, hematological, biochemical analysis, and histopathological examination were carried out.ResultsNo drug-induced abnormalities were found as clinical signs or in the histopathology, hematology, blood biochemistry, and urinalysis results for any administered doses of CGX.ConclusionThe results suggest that CGX is safe and could be considered as an effective and prospective herbal formulation in clinical applications with a wide therapeutic index.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 128, Issue 1, 2 March 2010, Pages 221–229
نویسندگان
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