Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice

The present study was designed to investigate how WE and CPs lessen insulin resistance and hyperglucemia in diabetic mice. As a result, WE and CPs increased the expression levels of InsR, IRS-1 and PI3K in kidney, and ameliorated glycogen content, glucokinase and glucose-6-phosphatase activities in liver, thereby eventually lessening insulin resistance and hyperglucemia.