کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2546903 1124040 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of antinociceptive activity of Casearia sylvestris and possible mechanism of action
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Evaluation of antinociceptive activity of Casearia sylvestris and possible mechanism of action
چکیده انگلیسی

The antinociceptive properties of Casearia sylvestris Sw. (Flacourtiaceae) were investigated in various models of pain-related behavior in mice. The hydroalcoholic crude extract of the plant (30–300 mg/kg, per os) clearly inhibited nocifensive responses induced by ovalbumin (hindpaw licking) or acetic acid (writhes) in graded fashion. At 300 mg/kg, the extract reduced nocifensive behaviors (from 71.1 ± 13.3 to 14.8 ± 9.3 s; from 31.3 ± 4.5 to 3.3 ± 1.2 writhes, respectively) to similar extents as indomethacin (5 mg/kg; 5.7 ± 1.1 s and 3.3 ± 1.2 writhes, respectively). Significant antinociceptive effects in the hot plate test were only detected following administration of the highest extract dose, but this analgesic action appeared to be specific as the extract failed to change motor and exploratory activities. The antinociceptive effect of Casearia sylvestris extract in the acetic acid test was prevented by prior treatment with the non-selective opioid receptor antagonist naloxone (1 mg/kg; 5.8 ± 4.2 and 31.5 ± 3.1 writhes in vehicle-treated and naloxone-treated groups, respectively), indicating that the endogenous opioid system is involved in its analgesic mechanism of action. Thus, our investigation suggests a potential therapeutic benefit of Casearia sylvestris Sw. in treating conditions associated with inflammatory pain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 112, Issue 1, 30 May 2007, Pages 1–6
نویسندگان
, , , , , ,