کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2546952 | 1124041 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effects of TGFβ1 and extracts from Cervus korean TEMMINCK var. mantchuricus Swinhoe on acute and chronic arthritis in rats Effects of TGFβ1 and extracts from Cervus korean TEMMINCK var. mantchuricus Swinhoe on acute and chronic arthritis in rats](/preview/png/2546952.png)
Aim of the StudyTo elucidate the pharmacological activities of deer antler acupuncture and TGF1 on the acute and chronic phases of rheumatoid arthritis diseases.Materials and MethodsPolyarthritis rats were administered with TGF1 and water extract of deer antler acupunture (DAA), prepared from the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe. TGF (0.1 to 2 g/animal) and DAA (5-100 g/kg animal) were initiated 1 day before an arthritogenic dose of streptococcal cell wall fragments to see the effects on the joint swelling and distortion during the acute phase and the chronic phase of the disease. Arthritic index suppression of rat arthritis model was examined by TGF and DAA administrations.ResultsTGF1 and DAA diminished the polyarthritis development in rats. TGF and DAA eliminated the joint swelling and distortion observed during the acute phase and the chronic phase of the disease. The TGF and DAA suppressed the arthritis progress when administration was begun after acute phase of arthritis.DiscussionConsistent with the inhibition of inflammatory cell recruitment into the synovium, TGF1 and DAA reversed the leukocytosis associated with the chronic phase of the arthritis, respectively.
Journal: Journal of Ethnopharmacology - Volume 118, Issue 2, 23 July 2008, Pages 280–283