کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2547169 1124049 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-arthritic activity of a biopolymeric fraction from Euphorbia tirucalli
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Anti-arthritic activity of a biopolymeric fraction from Euphorbia tirucalli
چکیده انگلیسی

The present study was undertaken to investigate the anti-arthritic activity of a biopolymeric fraction (BET) from plant Euphorbia tirucalli Boiss (Euphorbiaceae). The fraction showed dose dependent anti-arthritic activity and also showed in vivo immunomodulatory capacity being a major component in inhibiting arthritis. It caused suppression of CD4+ and CD8+ T cells, inhibition of intracellular Interleukin-2 (IL-2) and Interferon-gamma (IFN-γ) by flowcytometry. It inhibited vascular permeability and the migration of leucocytes at the site of the insult. The oral LD0 in both rats and mice was more than 2000 mg/kg.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 110, Issue 1, 1 March 2007, Pages 92–98
نویسندگان
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