کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2547444 1124058 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals
چکیده انگلیسی

Aim of the studyThe ethanol extract (LF) of Ligularia fischeri var. spiciformis (leaf) has been evaluated for antinociceptive and anti-inflammatory activities in mice.Materials and MethodsAnalgesic and anti-inflammatory activities were studied by measuring nociception induced by formalin, acetic acid and hot-plate, and inflammation induced by carrageenan, formalin, and arachidonic acid.ResultsThe acute treatment of mice with LF at doses of 100 and 200 mg/kg, by oral administration, produced a significant antinociceptive effect in the acetic acid-induced writhing, formalin-induced pain licking and hot-plate-induced pain. Also, the LF significantly inhibited both carrageenan- and formalin-induced inflammation as well as arachidonic acid-induced ear edema in mice.ConclusionsThese inhibitions were statistically significant (P < 0.05). Thus, our investigation suggests a potential benefit of Ligularia fischeri in treating conditions associated with inflammatory pain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 120, Issue 1, 30 October 2008, Pages 103–107
نویسندگان
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