کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2547487 | 1124060 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract](/preview/png/2547487.png)
The aqueous extract of the tuber of Smilax china L., popularly known in China as “Jin Gang Ten”, was tested for its anti-inflammatory activities in rats by egg-albumin-induced edema and anti-nociceptive effects in mice using hot-plate test and acetic acid-induced abdominal constriction test, respectively. The aqueous extract in the dose of 1000 mg/kg (i.g.) had a significant anti-nociceptive and anti-inflammatory effect compared to physiological saline. The anti-inflammatory effects are similar to acetylsalicylic acid (200 mg/kg, i.g.). We also evaluated the aqueous extract for the inhibition of prostaglandin production (for COX-2 inhibitions) in lipopolysaccharide (LPS)-induced mouse macrophage cells. The result showed that both COX-2 activity and COX expression were inhibited by the extract. These active extracts suppressing activities warranted further studies of active principles and development of new anti-inflammatory and analgesic agents. Studies to determine correlation between chemical composition and pharmacological activity are underway.
Journal: Journal of Ethnopharmacology - Volume 103, Issue 3, 20 February 2006, Pages 327–332