کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2547501 | 1124060 | 2006 | 5 صفحه PDF | دانلود رایگان |
In the present study, the effects of water–alcohol extract of Papaver rhoeas on the acquisition and expression of morphine-induced conditioned place preference (CPP) in mice were investigated. Subcutaneous (s.c.) administration of morphine (1, 10 and 20 mg/kg) produced place preference. On the other hand, intraperitoneal (i.p.) administration of the plant extract (25, 50 and 100 mg/kg) did not show any effect. Injection of extract (25, 50 and 100 mg/kg, i.p.) 30 min before the morphine administration decreased the acquisition of morphine CPP. Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test did not change the expression of morphine-induced CPP.It could be concluded that Papaver rhoeas reduced the acquisition but not the expression of morphine-induced conditioned place preference.
Journal: Journal of Ethnopharmacology - Volume 103, Issue 3, 20 February 2006, Pages 420–424