کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2547562 1124062 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lumbricus extract promotes the regeneration of injured peripheral nerve in rats
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Lumbricus extract promotes the regeneration of injured peripheral nerve in rats
چکیده انگلیسی

BackgroundEarthworms regenerate amputated parts of their body if the nervous system is intact. Lumbricus is one traditional Chinese medicine (TCM), which has been used in China to promote nerve function for hundreds of years.Aim of the studyTo investigate the beneficial effect of lumbricus extract on peripheral nerve regeneration in rats.Materials and methodsNerve function was surgically impaired in Sprague–Dawley (SD) rats by clamping of the left sciatic nerve. The sham-operated group (surgery but no sciatic nerve clamping), control group, and treatment group were treated with 2 ml 0.9% NaCl, 0.9% NaCl, and lumbricus extract (1 g/ml), respectively. Treatments were administered once daily after the operation for 6 weeks. During this period, motor function was monitored by walking track analysis, conduction function of injured sciatic nerve was monitored by electrophysiology, and regeneration of myelinated nerve was assessed by immunohistochemistry.Results(1) For nerve function index value, treatment group is higher than control group. (2) For conduction velocity of injured sciatic nerve, treatment group is higher than control group at week 3 and 6. (3) For the number of regenerated myelinated nerve fibers, treatment group is higher than control group at week 2 and 6.ConclusionsLumbricus extract appears to enhance sciatic nerve regeneration and function recovery following injury, suggesting the clinical potential of lumbricus extract on the treatment of peripheral nerve injury in humans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 123, Issue 1, 4 May 2009, Pages 51–54
نویسندگان
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