کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2547577 | 1124062 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Anti-inflammatory activity of Chrysanthemum indicum extract in acute and chronic cutaneous inflammation Anti-inflammatory activity of Chrysanthemum indicum extract in acute and chronic cutaneous inflammation](/preview/png/2547577.png)
Aim of the studyAlthough Chrysanthemum indicum Linné (Compositae) has long been used in traditional Korean, Chinese, Japanese medicine to treat various immune-related diseases the underlying mechanism(s) by which these effects are induced remains to be defined in vivo model system. We investigated the effects of 70% ethanolic extract from Chrysanthemum indicum Linné (CIE) on skin inflammation in mice.Materials and methodsProduction of pro-inflammatory cytokines (TNF-α and IL-1β), activation of myeloperoxidase, and histological assessment were examined in acute and chronic skin inflammation using 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema.ResultsCIE inhibited topical edema in the mouse ear, following administration at 200 mg/kg (i.p.), leading to substantial reductions in skin thickness and tissue weight, inflammatory cytokine production, neutrophil-mediated myeloperoxidase activity, and various histopathological indicators. Furthermore, CIE was effective at reducing inflammatory damage induced by chronic TPA exposure.ConclusionsThese results demonstrate that CIE is an effective anti-inflammatory agent in murine phorbol ester-induced dermatitis, and suggest that the extract may have therapeutic potential in a variety of immune-related cutaneous diseases.
Journal: Journal of Ethnopharmacology - Volume 123, Issue 1, 4 May 2009, Pages 149–154