کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2547734 1124067 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-plasmodial activity of the extracts of some Kenyan medicinal plants
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Anti-plasmodial activity of the extracts of some Kenyan medicinal plants
چکیده انگلیسی

Ethnopharmacological relevanceThe spread of drug resistant Plasmodium falciparum strains necessitates search for alternative newer drugs for use against malaria. Medicinal plants used traditionally in preparation of herbal medicines for malaria are potential source of new anti-malarial drugs.Aim of the StudyTo identify the anti-plasmodial potential of twelve plants used in preparing herbal remedies for malaria in Kilifi and Tharaka districts of Kenya.Materials and MethodsTwelve plants used traditionally for anti-malarial therapy in Kilifi and Tharaka districts were extracted with water/methanol yielding twenty-three extracts. The extracts were tested against chloroquine sensitive (NF54) and resistant (ENT30) P. falciparum strains in vitro using 3Hypoxanthine assay.ResultsSeven (30%) extracts showed activity against P. falciparum with IC50 values below 20 μg/ml. The remaining 16 extracts showed low or no activity. The most active extracts were from Zanthoxylum chalybeum (Rutaceae) with an IC50 value of 3.65 μg/ml, Cyperus articulatus (Cyperaceae) with 4.84 μg/ml, and Cissampelos pareira (Menispermaceae) with 5.85 μg/ml.ConclusionsThis study revealed plants, that are potential sources of anti-malarial compounds. Anti-plasmodial activities of extracts of T. simplicifolia, C. pareira, and C. articulatus are reported for the first time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 121, Issue 2, 21 January 2009, Pages 282–285
نویسندگان
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