کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2547812 | 1124070 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of Rubus coreanus on sperm parameters and cAMP-responsive element modulator (CREM) expression in rat testes
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of Rubus coreanus on sperm parameters and cAMP-responsive element modulator (CREM) expression in rat testes Effects of Rubus coreanus on sperm parameters and cAMP-responsive element modulator (CREM) expression in rat testes](/preview/png/2547812.png)
چکیده انگلیسی
Rubi Fructus (RF), the dried, unripe fruit of Rubus coreanus MIQ. (Rosaceae), has been used to improve male reproductive function in traditional Korean medicine. In this study, we investigated the effects of RF on sperm parameters and expression of cAMP-responsive element modulator (CREM), which has a crucial role in spermatogenesis. RF was administered to 8-week-old male Wistar rats for 56 consecutive days (1.0Â g/kg, daily, p.o.). Sperm analysis, RT-PCR, and Western blot assays were then carried out. The RF-treated animals showed significant increases in the weight of the testes, epididymal sperm count, and sperm motility compared to the control group. RF also increased the expression of CREM at both the mRNA and protein levels. These results suggest that RF may improve male fertility by enhancing spermatogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 114, Issue 3, 3 December 2007, Pages 463-467
Journal: Journal of Ethnopharmacology - Volume 114, Issue 3, 3 December 2007, Pages 463-467
نویسندگان
Myung Sook Oh, Woong Mo Yang, Mun Seog Chang, Wansu Park, Do Rim Kim, Hyun Kyung Lee, Won Nam Kim, Seong Kyu Park,