کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2547838 1124071 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-inflammatory activity of Trichodesma indicum root extract in experimental animals
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Anti-inflammatory activity of Trichodesma indicum root extract in experimental animals
چکیده انگلیسی

The chloroform extract of Trichodesma indicum root has been evaluated for anti-inflammatory activity against oedema produced by carrageenan, dextran, histamine and serotonin, and against formation of granulation tissues by cotton pellet in rats. The effect was compared with the activity of indomethacin, cyperoheptadine and dexamethasone against different types of inflammation. The chloroform extract at doses of 50, 100 and 200 mg/kg exhibited significant (P < 0.001) anti-inflammatory activity in acute and chronic inflammatory models. At 200 mg/kg the chloroform extract showed maximum inhibition of 48.12% in carrageenan-induced rat paw oedema while the standard indomethacin inhibited it by 54.32% after 3 h of carrageenan injection. The chloroform extract (50, 100 and 200 mg/kg) significantly (P < 0.001) and dose-dependently inhibited dextran, histamine and serotonin-induced rat paw oedema compared with control group (vehicle-treated). In the chronic inflammatory model, the chloroform extract (100 and 200 mg/kg) inhibited the granuloma weight by 15.42 and 21.12%, respectively, whereas the indomethacin and dexamethasone inhibited it by 29.29 and 34.13%, respectively. The results obtained suggest marked anti-inflammatory activity of the extract at the dose levels examined.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 104, Issue 3, 6 April 2006, Pages 410–414
نویسندگان
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