کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2547842 1124071 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effect of bioactive fraction of Sphaeranthus indicus Linn. against cyclophosphamide induced suppression of humoral immunity in mice
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Protective effect of bioactive fraction of Sphaeranthus indicus Linn. against cyclophosphamide induced suppression of humoral immunity in mice
چکیده انگلیسی

The bioactive fraction of Sphaeranthus indicus produced dose dependent increase in humoral immunity and delayed type hypersensitivity (DTH) response as evidenced by increased antibody production and increase in paw edema. The activity at higher doses, however, declines. Humoral antibody (HA) titre lowered by cyclophosphamide (CP) (p < 0.05) was enhanced by bioactive fraction at doses of 200 (p < 0.05) and 400 mg/kg (p < 0.001). There was dose dependent increase in HA titre in normal as well as immunosuppressed animals indicating that drug is effective in humoral immunity. Animals treated with cyclophosphamide and receiving bioactive fraction showed significant change in DTH response, which directly correlates with cell-mediated immunity, as compared to cyclophosphamide alone. Thus, it can be observed that a bioactive fraction of Sphaeranthus indicus acts as potentiator of DTH. Furthermore, the HPTLC fingerprint profile of the bioactive fraction was established to facilitate its identification and characterization. The results suggest that bioactive fraction influences both humoral and cell-mediated immunity and offers protection against immunosuppression induced by the cytotoxic agent cyclophosphamide.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 104, Issue 3, 6 April 2006, Pages 426–429
نویسندگان
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