کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2547992 1124077 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Buyang Huanwu Decoction promotes growth and differentiation of neural progenitor cells: Using a serum pharmacological method
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Buyang Huanwu Decoction promotes growth and differentiation of neural progenitor cells: Using a serum pharmacological method
چکیده انگلیسی

Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine, has been developed as a drug to be used for treatment of stroke for hundreds of years. However, the underlying mechanisms remain unknown. In this study, a serum pharmacological method was employed to investigate the effects of BYHWD on growth and differentiation of cultured neural progenitor cells derived from embryonic hippocampus. In culture medium containing BYHWD, the average neurite length of neural progenitor cells grew significantly longer than in control serum without BYHWD. Moreover, more neurofilament (NF) positive cells and glial fibrillary acidic protein (GFAP) positive cells were detected in the presence of BYHWD. The concentration of intracellular Ca2+ in progenitor cells cultured with BYHWD was significantly lower than that cultured without BYHWD. These results suggest that BYHWD may promote growth and differentiation of neural progenitor cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 113, Issue 2, 5 September 2007, Pages 199–203
نویسندگان
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