کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2548039 1124078 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Estimation of antinociceptive and anti-inflammatory activity on Geranium pratense subsp. finitimum and its phenolic compounds
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Estimation of antinociceptive and anti-inflammatory activity on Geranium pratense subsp. finitimum and its phenolic compounds
چکیده انگلیسی

To obtain experimental evidence on the therapeutic efficacy of Geranium species and its phenolic compounds for inflammatory diseases, we examined the effects of the aqueous extract of the aerial parts of Geranium pratense subsp. finitimum (Woronow) Knuth, its fractions and isolated compounds, the mixture of quercetin 3-O-α-arabinopyranoside, kaempferol 3-O-β-galactopyranoside (1), the mixture of quercetin 3-O-β-glucopyranoside, quercetin 3-O-β-galactopyranoside (2), kaempferol 3-O-β-glucopyranoside (3), (−)-6-chloroepicatechin (4), the mixture of quercetin 3-O-(2″-O-galloyl)-β-glucopyranoside, quercetin 3-O-(2″-O-galloyl)-β-galactopyranoside (5) and myricetin 3-O-(2″-O-galloyl)-β-glucopyranoside (6), on carrageenan-, PGE2- and TPA-induced inflammation in mice and p-benzoquinone-induced writhing reflex to assess anti-inflammatory and antinociceptive activities. The effective dose of materials for the inhibition of carragenan-induced hind paw edema assay was determined to be 100 mg/kg, which was also used in the assays with the extract, its fractions and isolated compounds in all other experiments. The aqueous extract, 1, 2 (100 mg/kg), as well as indomethacin (10 mg/kg) inhibited significantly the formation of the carrageenan-induced hind paw edema. There was also a significant reduction in PGE2-induced hind paw edema and TPA-induced ear edema models with 5, in addition to the aqueous extract and the other active components 1 and 2. In the antinociceptive assay, the aqueous extract and its fractions, as well as 1, 2, and 5 diminished significantly the number of writhings. Based on the results obtained it is suggested that the aqueous extract of Geranium pratense subsp. finitimum and its phenolic compounds display anti-inflammatory activity, supporting the folkloric use.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 114, Issue 2, 1 November 2007, Pages 234–240
نویسندگان
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