کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2548204 1124088 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice
چکیده انگلیسی

The present study was designed to determine in vivo efficacy of Ganoderma lucidum polysaccharides (Gl-PS) for enhancing the activity of immunological effector cells in immunosuppressed mice. Mice were injected intraperitoneally (i.p.) once daily with low-dose (2.5 mg/kg), intermediate-dose (25 mg/kg), and high-dose (250 mg/kg) of Gl-PS, respectively, for 7 consecutive days 24 h after i.p. injection of a immunosuppressing anti-tumor agent cyclophosphamide (Cy, 300 mg/kg). In Cy-treated mice, compared to vehicle, low-dose Gl-PS accelerated recovery of bone marrow cells, red blood cells and white blood cells, as well as splenic natural killer cells and natural killer T cells, and enhanced T and B cell proliferation responses on day 8, cytotoxic T lymphocyte activity on day 5, as well as NK cell and lymphokine activated killer cell activity on days 7–9. Furthermore, it promoted phagocytosis and cytotoxicity of macrophages on day 12. The above beneficial effects induced by the low-dose Gl-PS treatment did not result in any side effects. These results demonstrate the efficacious effects of low-dose Gl-PS treatment for enhancing the activity of immunological effector cells in immunosuppressed mice, and may provide a basis for applying this herb as an efficacious adjacent immunopotentiating therapy against cancer chemotherapy-induced immunosuppression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 111, Issue 2, 4 May 2007, Pages 219–226
نویسندگان
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