کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2548326 1124097 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antithrombotic activity of methanolic extract of Umbilicaria esculenta
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Antithrombotic activity of methanolic extract of Umbilicaria esculenta
چکیده انگلیسی

Antithrombotic activity of methanolic extract of an edible lichen, Umbilicaria esculenta, was evaluated on platelet aggregation in vitro and pulmonary thrombosis in vivo. The extract showed concentration dependent inhibitory effects on platelet aggregation induced by ADP, with IC50 value of 2.4 mg/mL. Orally administered extract protected mice against thrombotic death or paralysis induced by collagen and epinephrine in a dose dependent manner. It produced a significant inhibition of thrombotic death or paralysis at over 100 mg/kg body weight, while aspirin produced a significant inhibition of thrombosis at 10–20 mg/kg body weight. Mouse tail bleeding time was significantly prolonged by addition of the extract. On the other hand, the extract did not show any fibrinolytic activity and alter coagulation parameters such as activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) in rat platelet. These results suggested that the antithrombotic activity of Umbilicaria esculenta extract might be due to antiplatelet activity rather than anticoagulation activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 105, Issue 3, 24 May 2006, Pages 342–345
نویسندگان
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