کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2548366 | 1560411 | 2006 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa](/preview/png/2548366.png)
The pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa were carried out. The 75% ethanol extract (100–400 mg/kg) of Gentianopsis paludosa inhibited castor oil-induced diarrhoea and also reduced gastrointestinal motility in the charcoal meal test in mice. In the rabbit-isolated ileum, the extract showed inhibitory effects not only on its spontaneous contraction, but also on acetylcholine (Ach, 0.1 mM)- and KCl (60 mM)-induced contractions. Furthermore, the ethanol extract (0.4–0.6 mg/ml) shifted the CaCl2 dose–effect curves to the right in a non-competitive manner and significantly reduced the acetylcholine-induced contraction of isolated ileum in Ca2+-free solution like verapamil (0.1 mM), which suggest that the extract interferes with Ca2+ movement. These results support the traditional use of Gentianopsis paludosa in the treatment of diarrhoea.
Journal: Journal of Ethnopharmacology - Volume 105, Issues 1–2, 21 April 2006, Pages 114–117