Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis

► The anti-fibrotic effects of imatinib, nilotinib and silymarin were compared. ► These effects were evaluated on CCl4-induced hepatic fibrosis in rats. ► Nilotinib was found to possess potent anti-fibrotic activity. ► In addition, nilotinib did not show any signs of hepatotoxicity. ► Thus, nilotinib may be valuable in the treatment of hepatic fibrosis in humans.