کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2569979 1128561 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals
چکیده انگلیسی

The algorithms in the literature focusing to predict tissue:blood PC (Ptb) for environmental chemicals and tissue:plasma PC based on total (Kp) or unbound concentration (Kpu) for drugs differ in their consideration of binding to hemoglobin, plasma proteins and charged phospholipids. The objective of the present study was to develop a unified algorithm such that Ptb, Kp and Kpu for both drugs and environmental chemicals could be predicted. The development of the unified algorithm was accomplished by integrating all mechanistic algorithms previously published to compute the PCs. Furthermore, the algorithm was structured in such a way as to facilitate predictions of the distribution of organic compounds at the macro (i.e. whole tissue) and micro (i.e. cells and fluids) levels. The resulting unified algorithm was applied to compute the rat Ptb, Kp or Kpu of muscle (n = 174), liver (n = 139) and adipose tissue (n = 141) for acidic, neutral, zwitterionic and basic drugs as well as ketones, acetate esters, alcohols, aliphatic hydrocarbons, aromatic hydrocarbons and ethers. The unified algorithm reproduced adequately the values predicted previously by the published algorithms for a total of 142 drugs and chemicals. The sensitivity analysis demonstrated the relative importance of the various compound properties reflective of specific mechanistic determinants relevant to prediction of PC values of drugs and environmental chemicals. Overall, the present unified algorithm uniquely facilitates the computation of macro and micro level PCs for developing organ and cellular-level PBPK models for both chemicals and drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 249, Issue 3, 15 December 2010, Pages 197–207
نویسندگان
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