Interleukin-6 production by peritoneal mesothelial cells and its regulation by inflammatory factors in rats administered carbon tetrachloride intraperitoneally

In summary, the present study indicates that the high level of IL-6 observed in the rat peritoneal cavity after ip CCl4 administration is at least partially produced by PMCs stimulated cooperatively with IL-1α, IL-1β, TNF-α and PGE2. These inflammatory factors may be released from tissues or cells either stimulated or injured directly by CCl4.