کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2571027 1128613 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde
چکیده انگلیسی

Induction of airway hyperresponsiveness and asthma from formaldehyde inhalation exposure remains a debated and controversial issue. Yet, recent evidences on pulmonary biology and the pharmacokinetics and toxicity of formaldehyde lend support for such adverse effects. Specifically, altered thiol biology from accelerated enzymatic reduction of the endogenous bronchodilator S-nitrosoglutathione and pulmonary inflammation from involvement of Th2-mediated immune responses might serve as key events and cooperate in airway pathophysiology.Understanding what role these mechanisms play in various species and lifestages (e.g., child vs. adult) could be crucial for making more meaningful inter- and intra-species dosimetric extrapolations in human health risk assessment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 233, Issue 3, 15 December 2008, Pages 355–359
نویسندگان
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