کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2572541 1129305 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exploring the potential of adjunct therapy in tuberculosis
ترجمه فارسی عنوان
بررسی پتانسیل درمان جانبی در سل
کلمات کلیدی
درمان دارویی تحت درمان با میزبان، داروهای تجویز شده، پمپ خروجی، عوامل ویروسی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


• Proof-of-concept in animal models demonstrated for modulation of eicosanoid levels.
• Repurposing metformin a commonly used antidiabetic drug for TB holds promise.
• Novel strategy of targeting granuloma-associated angiogenesis uncovered.
• Verapamil is an antihypertensive drug is poised to enter clinical trials as adjunct therapy.

A critical unmet need for treatment of drug-resistant tuberculosis (TB) is to find novel therapies that are efficacious, safe, and shorten the duration of treatment. Drug discovery approaches for TB primarily target essential genes of the pathogen Mycobacterium tuberculosis (Mtb) but novel strategies such as host-directed therapies and nonmicrobicidal targets are necessary to bring about a paradigm shift in treatment. Drugs targeting the host pathways and nonmicrobicidal proteins can be used only in conjunction with existing drugs as adjunct therapies. Significantly, host-directed adjunct therapies have the potential to decrease duration of treatment, as they are less prone to drug resistance, target the immune responses, and act via novel mechanism of action. Recent advances in targeting host–pathogen interactions have implicated pathways such as eicosanoid regulation and angiogenesis. Furthermore, several approved drugs such as metformin and verapamil have been identified that appear suitable for repurposing for the treatment of TB. These findings and the challenges in the area of host- and/or pathogen-directed adjunct therapies and their implications for TB therapy are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 36, Issue 8, August 2015, Pages 506–513
نویسندگان
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