کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2572871 1129334 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human cytosolic glutathione transferases: structure, function, and drug discovery
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Human cytosolic glutathione transferases: structure, function, and drug discovery
چکیده انگلیسی

Glutathione transferases (GSTs) are important detoxifying enzymes that catalyze the conjugation of electrophilic substrates to glutathione. In recent years, GSTs have been of great interest in pharmacology and drug development because of their involvement in many important biological processes such as steroid and prostaglandin biosynthesis, tyrosine catabolism, and cell apoptosis. This review describes crystal structures for cytosolic GSTs and correlates active-site features with enzyme functions (e.g., steroid synthesis, tyrosine degradation, and dehydroascorbate reduction) and substrate selectivity. Use of these crystal structures for the design of specific inhibitors for several GST enzymes is also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 33, Issue 12, December 2012, Pages 656–668
نویسندگان
, ,