کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2572894 1129336 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammation and neurodegeneration: the story ‘retolled’
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Inflammation and neurodegeneration: the story ‘retolled’
چکیده انگلیسی

Toll-like receptors (TLRs) play a crucial role in innate immunity by recognizing conserved motifs predominantly found in microorganisms. Increasing evidence supports a role for TLRs in sterile inflammation as observed in neurodegenerative disorders. This includes work suggesting a contribution for these receptors to the pathophysiology of Alzheimer's disease (AD), Parkinson's disease (PD), and related disorders. In this review, the potential role of TLRs in the context of protein aggregation, neuronal degeneration, and genetic risk factors is addressed. In particular, we discuss the evidence derived from experimental models of both AD and PD which suggests that activation of TLRs can have beneficial and detrimental effects on pathological features such as protein aggregation and neuronal death. A deeper understanding of these dichotomous observations could be used for therapeutic benefit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 33, Issue 10, October 2012, Pages 542–551
نویسندگان
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