کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2572922 1129338 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Valley of Death in anticancer drug development: a reassessment
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
The Valley of Death in anticancer drug development: a reassessment
چکیده انگلیسی

The past decade has seen an explosion in our understanding of cancer biology and with it many new potential disease targets. Nonetheless, our ability to translate these advances into therapies is poor, with a failure rate approaching 90%. Much discussion has been devoted to this so-called ‘Valley of Death’ in anticancer drug development, but the problem persists. Could we have overlooked some straightforward explanations to this highly complex problem? Important aspects of tumor physiology, drug pharmacokinetics, preclinical models, drug delivery, and clinical translation are not often emphasized, but could be crucial. This perspective summarizes current views on the problem and suggests feasible alternatives.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 33, Issue 4, April 2012, Pages 173–180
نویسندگان
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