کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2573210 1129364 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-genomic loss of PTEN function in cancer: not in my genes
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Non-genomic loss of PTEN function in cancer: not in my genes
چکیده انگلیسی

Loss of function of the phosphatase and tensin homolog (PTEN) tumour suppressor contributes to the development of many cancers. However, in contrast to classical models of tumour suppression, partial loss of PTEN function appears to be frequently observed in the clinic. In addition, studies of both humans and mice with reductions in PTEN gene dosage indicate that even partial loss of PTEN function is sufficient to promote some cancer types, particularly in the breast. PTEN expression appears to be tightly controlled both transcriptionally and post-transcriptionally, with several recent studies implicating oncogenic microRNAs in PTEN suppression. The lipid phosphatase activity of PTEN can also be regulated post-translationally via inhibitory phosphorylation, ubiquitination or oxidation. Here we discuss these multiple mechanisms of PTEN regulation. We also put into context recent proposals that changes in this regulation can drive tumour development and address the accompanying evidence for their clinical significance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 32, Issue 3, March 2011, Pages 131–140
نویسندگان
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