کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2573617 1129399 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Is chemical genetics the new frontier for malaria biology?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Is chemical genetics the new frontier for malaria biology?
چکیده انگلیسی

Malaria is a global disease, causing at least 500 million clinical cases and more than one million deaths each year. Moreover, drug-resistant Plasmodium falciparum, the organism that causes most malaria-associated deaths, has become a major problem. Therefore, discovery and investigation of novel targets for anti-malarial drug design is essential to combat this disease. The malarial genome has been sequenced, revealing ∼5500 genes. The current post-genomic challenge is functionally to evaluate the essential genes and validate them for therapeutic design. Unfortunately, standard genetics techniques are limited in scope because of low transfection efficiency and a lack of knockdown techniques, thereby rendering the analysis of essential genes difficult.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 29, Issue 2, February 2008, Pages 51–56
نویسندگان
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