Protective effect of N-acetylcysteine on cyclophosphamide-induced cardiotoxicity in rats

- Cyclophosphamide is known to cause severe cardiac toxicity.
- N-acetylcysteine (NAC) is an antioxidant with free radical scavenging activity.
- CP increased the serum cardiac enzymes, ADMA, TNF-α and decreased the NOx.
- NAC pretreatment protects against CP-induced cardiotoxicity.
- NAC inhibits oxidative and nitrosative stress induced by CP.