کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2582922 1130675 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alterations in the serum biomarkers belonging to different metabolic systems of fish (Oreochromis niloticus) after Cd and Pb exposures
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Alterations in the serum biomarkers belonging to different metabolic systems of fish (Oreochromis niloticus) after Cd and Pb exposures
چکیده انگلیسی
The serum of vertebrates including human gives sufficient data about the current health status of organism in concern. Biomarkers have gained importance in evaluation of data from biological monitoring studies. In this study, freshwater fish Oreochromis niloticus were individually exposed Cd or Pb using acute (10 μM, 2 d) and chronic (20 μM, 20 d) exposure protocols to investigate the alterations in serum parameters (ALP, ALT, AST, LDH, lipase, glucose, protein, cholesterol and triglyceride) and response of the endocrine system functioning in different axis, namely HPI (cortisol), HPT (TSH, T3, T4), gonadal (LH, FSH) and prolactin. Data showed that except LH, the levels of all hormones decreased significantly following exposure to Cd and Pb both in acute and chronic exposures. In acute exposures, the activity of ALP and levels of cholesterol and triglyceride decreased significantly following both Cd and Pb exposures, while glucose levels increased only after Cd exposure. In chronic exposures, both metal exposures caused significant decreases in ALP activity and levels of cholesterol and triglyceride, though there were increases in glucose level after Cd exposure and AST, ALT and LDH levels after Pb exposure. Data emphasized the importance of biomarker selection and multiparameter usage of relevant systems in ecotoxicological research to achieve proper evaluation of environmental data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 40, Issue 2, September 2015, Pages 508-515
نویسندگان
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