کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2582995 1130677 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM-1 protects against gamma radiation-induced oxidative stress
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM-1 protects against gamma radiation-induced oxidative stress
چکیده انگلیسی


• SQGD inhibits γ radiation-induced in vitro toxicity.
• SQGD inhibits radiation-induced carbonylation in proteins.
• SQGD protects enzymes against radiation-induced inactivation.
• SQGD protect DNA from radiation-induced damage.
• SQGD protects lipid peroxidation in brain, intestine and liposomal membrane.

In the present study, radioprotective potential of Semiquinone glucoside derivative (SQGD) isolated from radioresistant bacterium Bacillus sp. INM-1 was evaluated. γ-Radiation induced protein carbonylation, plasmid DNA damage, enzyme functional impairment, lipid peroxidation, HO radicals generation and their protection by SQGD was assessed. As a result of SQGD treatment, significant inhibition (p < 0.05) in protein carbonylation was observed with BSA. SQGD treatment was found to restore supercoiled (∼70 ± 3.21%) form of irradiated plasmid DNA against γ-irradiation. SQGD protects enzymes (EcoR1 and BamH1) against radiation-induced dysfunctioning. SQGD significantly inhibited (p < 0.05) lipid peroxidation in liposomes, brain and liver homogenate. Higher HO
• radicals-averting activity of SQGD was observed in the serum and liver homogenate of C57BL/6 mice against H2O2-induced oxidative stress. In conclusion, SQGD demonstrates excellent radical-scavenging activity towards bio-macromolecules in irradiated environment and can be developed as an ideal radioprotector against radiation-induced oxidative stress in future.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 37, Issue 2, March 2014, Pages 553–562
نویسندگان
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