کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2583086 1130679 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intervention of selenium on apoptosis and Fas/FasL expressions in the liver of fluoride-exposed rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Intervention of selenium on apoptosis and Fas/FasL expressions in the liver of fluoride-exposed rats
چکیده انگلیسی
Fluorosis is a major public health problem in numerous areas around the world, including China. To alleviate this problem, selenium has been used. In this study, we aimed to investigate the influence of selenium on apoptosis in fluorosis-affected rat livers and determine the optimal selenium concentration in drinking water to fight fluorosis. The protein levels of Fas in NaF and NaF + Se (0.375 and 0.75 mg/L) groups as well as FasL in NaF, Se (0.75 and 1.5 mg/L), and NaF + Se (0.375 mg/L) groups were significantly increased compared with those in the control group. The mRNA levels of Fas in NaF and Se (1.5 mg/L) groups as well as FasL in NaF and NaF + Se (0.375 mg/L) groups were significantly increased. The protein levels of Fas in NaF + Se (1.5 mg/L) group and FasL in three NaF + Se groups were significantly decreased compared with those in the NaF group. The mRNA levels of Fas in the three NaF + Se groups and FasL in NaF + Se (0.75 and 1.5 mg/L) groups were significantly decreased. Compared with the control group, activity of GSH-Px, and SOD in the NaF group decreased obviously and MDA content increased obviously; activity of SOD in 1.5 mg/L Se group decreased obviously. Compared with the NaF group, activity of GSH-Px in NaF + Se (1.5 mg/L) group significantly increased, and MDA content decreased obviously. Thus, fluoride induced apoptosis in the liver, thereby causing liver damage in the rats. Selenium could alleviate fluorosis-induced liver injury. In particular, selenium at 1.5 mg/L is considered the optimum concentration against fluorosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 36, Issue 3, November 2013, Pages 913-920
نویسندگان
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