کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2583162 | 1130680 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extreme differences in SLCO1B3 functional polymorphisms in Roma and Hungarian populations
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کلمات کلیدی
RT-PCROATPAUC - AUCRoma - رمPCR-RFLP - روش PCR-RFLPReal time-polymerase chain reaction - زمان واقعی واکنش زنجیره ای پلیمرازLinkage disequilibrium - عدم تعادل پیوستگیHungarian - مجارستانیPolymorphism - پلی مورفیسمpolymerase chain reaction-restriction fragment length polymorphism - پلیمورفیسم طول قطعه واکنش زنجیره پلیمرازOrganic anion transporting polypeptide - پلیپپتید حمل آنیون ارگانیکSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Extreme differences in SLCO1B3 functional polymorphisms in Roma and Hungarian populations Extreme differences in SLCO1B3 functional polymorphisms in Roma and Hungarian populations](/preview/png/2583162.png)
چکیده انگلیسی
Variants in SLCO1B3 transporter are linked to disposition and uptake of drugs and show high degree of heterogeneity between populations. A total of 467 Roma and 448 Hungarian subjects were genotyped for SLCO1B3 c.334T>G and c.1683-5676A>G variant alleles by PCR-RFLP assay and direct sequencing. We found significant differences in the frequencies of homozygous variant genotypes of SLCO1B3 334GG (41.54% vs. 8.04%, p < 0.001) and 1683-5676GG (0.43% vs. 2.01%, p = 0.028) between Romas and Hungarians. A significantly increased prevalence was found in SLCO1B3 1683-5676G allele frequency in Hungarians compared to the Roma population (15.07% vs. 3.43%, p â¤Â 0.001). The frequency of SLCO1B3 334G allele was significantly increased in Roma population compared to Hungarians (70.56% vs. 52.23%, p = 0.001). The LD values between the examined SNPs were 80 and 90 in Roma and in Hungarian samples, respectively. Our results highlight notable pharmacogenetic differences between Roma and Hungarian populations, which may have therapeutic implications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 39, Issue 3, May 2015, Pages 1246-1251
Journal: Environmental Toxicology and Pharmacology - Volume 39, Issue 3, May 2015, Pages 1246-1251
نویسندگان
Agnes Nagy, Renata Szalai, Lili Magyari, Judit Bene, Kalman Toth, Bela Melegh,