کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2583348 1130687 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Therapeutic efficiency of succimer used with calcium and ascorbic acid in the treatment of mild lead-poisoning
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Therapeutic efficiency of succimer used with calcium and ascorbic acid in the treatment of mild lead-poisoning
چکیده انگلیسی

The aim of this study was to explore therapeutic efficiency of succimer used with calcium and ascorbic acid in the treatment of mildly lead-poisoned mice and preschool children. Mice were exposed to lead by drinking water, and then treated with saline solution, 50 mg/kg body weight (b.w.) succimer, 100 mg/kg b.w. succimer, or 50 mg/kg b.w. succimer plus calcium and ascorbic acid by gavage. Seventy-two children aged 48–72 months were randomly assigned into combined treatment or nutritional intervention group. Lead levels in blood and bone were analyzed by atomic absorption spectrophotometry. Activities of aminolevulinic acid dehydratase (ALAD) in blood were determined by colorimetric method. Results of animal experiment showed that succimer used alone could reduce lead levels in blood and bone and reverse activities of ALAD in blood, however, a better therapeutic efficiency in mobilizing bone lead could be achieved by succimer used with calcium and ascorbic acid. Findings from the clinical study showed that reduction of blood lead levels (BLLs) between the end and initiation of therapy in the combined treatment group was significantly greater than that in the nutritional intervention group. Percentage of children with BLLs less than 10 μg/dL at the end of therapy and the eighth week after therapy in the combined treatment group was significantly higher than that in the nutritional intervention group. In conclusion, combined use of succimer with calcium and ascorbic acid seemed to be a choice in the treatment of mildly lead poisoned children.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 31, Issue 1, January 2011, Pages 137–142
نویسندگان
, , , , , , ,