کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2583381 1561705 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead
چکیده انگلیسی

Quercetin, a flavonoid, effectively improved the lead-induced histology changes including structure damage and leukocyte infiltration in rat kidney. The present study was designed to explore the protective mechanism of quercetin against lead-induced oxidative DNA damage and apoptosis in rat kidney. We found that quercetin markedly decreased the ROS level and lowered the GSH/GSSG ratio in the kidney of lead-treated rat. The increase of 8-hydroxydeoxyguanosine level in the kidney of lead-treated rat was effectively suppressed by quercetin. Furthermore, quercetin markedly restored Cu/Zn-SOD, CAT and GPx activities in the kidney of lead-treated rat. TUNEL assay showed that lead-induced apoptosis in rat kidney was significantly inhibited by quercetin, which might be attributed to its antioxidant property. In conclusion, these results suggested that quercetin could protect the rat kidney against lead-induced injury by improving renal function, attenuating histopathologic changes, reducing ROS production, renewing the activities of antioxidant enzymes, decreasing DNA oxidative damage and apoptosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 30, Issue 3, November 2010, Pages 264–271
نویسندگان
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