DNA polymerase beta is involved in the protection against the cytotoxicity and genotoxicity of cigarette smoke

▸ polβ−/−, polβ+/+ and polβoe cells were first used to evaluate the toxicity of CSE. ▸ The toxicity of cigarette smoke should be due to ROS-mediated DNA damage. ▸ polβ involves in protection against cytotoxicity and genotoxicity of cigarette smoke.