کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2583545 | 1130693 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of repeated exposure to decabrominated diphenyl ether (BDE-209) on mice nervous system and its self repair
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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![عکس صفحه اول مقاله: Effects of repeated exposure to decabrominated diphenyl ether (BDE-209) on mice nervous system and its self repair Effects of repeated exposure to decabrominated diphenyl ether (BDE-209) on mice nervous system and its self repair](/preview/png/2583545.png)
چکیده انگلیسی
Decabrominated diphenyl ether (BDE-209) is widely used as brominated flame retardants (BFRs). In order to investigate its direct neurotoxic effects on mice and its self repair, mice were repeatedly exposured to BDE-209. Different concentrations of BDE-209 (0, 0.1, 40, 80 and 160 mg/kg bw/d) were administered daily to CD-1 Swiss mice by gavage for 15, 30 and 60 days. Body and brain weights were recorded after the exposure. And the self repair was studied. Levels of acetylcholinesterase (TchE), superoxide dismutase (SOD) and malonic dialdehyde (MDA) in brain were analyzed. Experimental results suggested that the nervous system was permanently damaged by BDE-209 through the cholinergic system enzyme.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 29, Issue 3, May 2010, Pages 297–301
Journal: Environmental Toxicology and Pharmacology - Volume 29, Issue 3, May 2010, Pages 297–301
نویسندگان
Shu-xuan Liang, Hong-xia Gao, Yan-yan Zhao, Xiao-mei Ma, Han-wen Sun,