Isolation and structural elucidation of two secondary metabolites from the filamentous fungus Penicillium ochrochloron with antimicrobial activity

In this investigation, the extracts of filamentous fungi exhibited inhibitory effect on the growth of Gram positive and Gram negative bacteria, as well as against the yeast Candida albicans. Penicillium ochrochloron has been proven as the most active fungus against all tested microorganisms. Further bio-guided chemical analysis of P. ochrochloron afforded two components with antimicrobial activity identified as (−) 2, 3, 4-trihydroxybutanamide and (−) erythritol.