کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2583910 | 1130707 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induction of oxidative stress by lindane in epididymis of adult male rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Lindane, an organochlorine pesticide, has been reported to induce reproductive abnormalities in male rats. The mechanism of action of lindane on male reproductive system remains unclear. In the present study we have sought to investigate the effect of lindane on antioxidant parameters and sialic acid levels of caput, corpus and cauda epididymis of adult male rats. Lindane (1, 5, and 50Â mg/kg per day) was administered orally to adult male rats for 45 days. The animals were killed using anaesthic ether on the day following the last treatment. The body weight of the animals did not show significant change. However, the weights of caput, corpus and cauda epididymis decreased in lindane treated animals. Administration of lindane caused decrease in epididymal sperm count and motility. Sialic acid levels in the epididymis decreased significantly at 5 and 50Â mg/kg dosage of lindane treatment. Significant decline in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase along with increase in hydrogen peroxide generation and lipid peroxidation were observed in lindane treated animals. In conclusion, lindane induces oxidative stress by decreasing the activities of antioxidant enzymes and sialic acid levels in the epididymis thereby causing impaired sperm function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 22, Issue 1, July 2006, Pages 90-96
Journal: Environmental Toxicology and Pharmacology - Volume 22, Issue 1, July 2006, Pages 90-96
نویسندگان
B. Saradha, P.P. Mathur,