کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2584143 | 1130716 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pentachlorophenol inhibits micronuclei induction by 2-acetylaminofluorene but not by thioacetamide
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pentachlorophenol inhibits micronuclei induction by 2-acetylaminofluorene but not by thioacetamide Pentachlorophenol inhibits micronuclei induction by 2-acetylaminofluorene but not by thioacetamide](/preview/png/2584143.png)
چکیده انگلیسی
Our study examined the capacity of pentachlorophenol (PCP) to inhibit the ability of 2-acetylaminofluorene (2-AAF) and thioacetamide (TAA) to induce micronuclei in mouse bone marrow cells in vivo. 2-AAF (5.6Â mg/kg) and TAA (60Â mg/kg) were administered intra-peritoneally (i.p.) to Mus musculus males (BALB/c), and the frequencies of polychromatic erythrocytes with micronuclei (PCE-MN) 24Â h after injection were analyzed. Treatment with 2-AAF or TAA resulted in high PCE-MN frequencies in comparison with untreated and negative controls (19.9 and 21.6â°, respectively, versus â3â°). Pretreatment with a single PCP dose (44Â mg/kg) 24Â h prior to the 2-AAF administration virtually eliminated micronuclei formation by 2-AAF, although it had no inhibitory effect on TAA-induced micronuclei. Animals receiving cyclophosphamide (CP) served as positive control. Since PCP is known to inhibit arylsulfotransferase (AST) activity, which is involved in 2-AAF activation, this mechanism most likely produced the results with PCP and 2-AAF. Our results also are consistent with a different pathway involved in TAA induction of micronuclei, one that is not inhibited by PCP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 21, Issue 1, January 2006, Pages 56-60
Journal: Environmental Toxicology and Pharmacology - Volume 21, Issue 1, January 2006, Pages 56-60
نویسندگان
E. Zamorano-Ponce, J. Fernández Romero, P. Rivera Caamaño, C. Barrios Guerra,