کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2584404 1130735 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
2-(4′-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
2-(4′-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres
چکیده انگلیسی

The toxicity of polychlorinated biphenyls (PCBs) has been attributed widely to receptor-mediated effects, buttressed by the popularity of the toxic equivalency factor. We propose that a crucial toxic mechanism of lower chlorinated PCBs is their enzymatic biotransformation to electrophiles, including quinoid metabolites, that bind intracellular sulfhydryl groups, such as those found in microtubulin and enzymes like telomerase. To test this hypothesis, we have examined micronuclei induction, cell cycle, and telomere shortening in cells in culture. Our findings show a large increase in micronuclei frequency and cell cycle perturbation in V79 cells, and a marked decrease in telomere length in HaCaT cells exposed to 2-(4′-chlorophenyl)-1,4-benzoquinone (PCB3pQ).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 25, Issue 2, March 2008, Pages 267–272
نویسندگان
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