کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2586140 | 1130893 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Safety studies of pseudo-ceramide SLE66. Part 3: Effects on embryo/fetal development in rats
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کلمات کلیدی
OECDPKCNOAELPseudo-ceramideSafety - ایمنیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceTeratology - تراتولوژیgestation day - روز بارداریOrganization for Economic Cooperation and Development - سازمان همکاری های اقتصادی و توسعهDevelopmental toxicity - سمیت توسعهno-observed-adverse-effect level - هیچ عارضه ای مشاهده نشدProtein kinase C - پروتئین کیناز سی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
SLE66 a synthetic pseudo-ceramide, has been shown to reduce dryness/scaling/itching of human skin. Naturally occurring ceramides have been claimed to play a crucial role in cell proliferation, differentiation, and apoptosis including processes important for embryogenesis. The objective of this study was to evaluate the potential maternal and fetal effects of SLE66. SLE66 was administered orally (gavage) to mated female Crl:CD®(SD)IGS BR rats (25/group) once daily from gestation day 6 through 19, at dose levels of 0 (control), 150, 400 or 1000Â mg/kg/day. No treatment-related clinical or internal (macroscopic) findings were noted and all animals survived to the scheduled necropsy on gestation day 20. SLE66 administration did not affect mean maternal body weights, body weight gains, net body weights, net body weight gains, gravid uterine weights, or feed consumption. Similarly, SLE66 administration did not affect intrauterine growth and survival related parameters such as viable fetuses, pre-implantation loss, early and late resorptions, fetal weight and fetal sex. No SLE66-related fetal malformations or developmental variations were noted. Based on the results of this study, a dose level of 1000Â mg/kg/day (highest dose used) was considered as the no-observed-adverse-effect level (NOAEL) for both maternal and developmental toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 47, Issue 4, April 2009, Pages 681-686
Journal: Food and Chemical Toxicology - Volume 47, Issue 4, April 2009, Pages 681-686
نویسندگان
Osamu Morita, John F. Knapp, Yasushi Tamaki, Donald G. Stump, Mark D. Nemec, Koichi Yoshimura,